Evidence of focusing the MHC class I immunopeptidome by tapasin

Major Histocompatibility Complex class I (MHC-I) molecules bind and present peptides to cytotoxic T cells, protecting against pathogens and cancer.MHC-I is highly polymorphic and each allotype is promiscuous, and capable of binding a unique and diverse repertoire of peptide ligands.The peptide editing chaperone tapasin optimizes this allotype speci

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Ecophysiological consequences of variability in diapause intensity

mpu63zm/a Diapause intensity (DI) is a physiological trait represented by the duration of diapause under given conditions of environment.In many species, it is highly variable, probably being controlled by multiple genes and tends to form a cline in response to the latitudinal gradient of selection pressure.DI clines could be established artificial

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Waterhouse Friderichsen Syndrome: Medico-legal issues

The Waterhouse-Friderichsen Syndrome (WFS) is a pediatric emergency characterized by high mortality due to the combination of bilateral adrenal haemorrhage, meningococcal infection and cutaneous purpura.WFS often raises medico-legal problems related to missed or delayed diagnosis mainly related to the short clinical course, the sudden onset of flex

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